What are the side effects of Onsior for cats?


What are the side effects of Robenacoxib in cats?

To evaluate the safety of robenacoxib tablets when administered to cats that received the test article at 1 (2.4 mg/kg), 3 (7.2 mg/kg), and 5 (12 mg/kg) times the maximum targeted exposure once daily. 8 month-old, healthy cats. The most common adverse reactions were vomiting, decreased activity, injected sclera and soft stools.

Is Robenacoxib a COX-2 inhibitor?

In an inflammation model in cats, robenacoxib had analgesic, antiinflammatory and anti-pyretic actions with a rapid onset of action (0.5 h). 1 In an in vitro whole blood assay in cats, robenacoxib demonstrated selective COX-2 inhibition. 2 The clinical relevance of this data has not been shown. Robenacoxib is an analog of diclofenac.

How long does it take for Robenacoxib to work?

This medication will take effect quickly, in about 1 to 2 hours, and improvement in clinical signs should follow. Are there any potential side effects from robenacoxib?

What are the side effects of Robenacoxib for dogs?

Are there any potential side effects from robenacoxib? While most pets do well with robenacoxib, pets that are hypersensitive to it or other NSAIDs could have side effects including anorexia (lack of appetite), lethargy, depression, vomiting, diarrhea, kidney disease, and kidney failure. Bleeding or infection at the incision site is also possible.

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Is Robenacoxib safe for cats with osteoarthritis?

Clinical safety of robenacoxib in feline osteoarthritis: results of a randomized, blinded, placebo-controlled clinical trial Robenacoxib was well tolerated when administered daily for 1 month in cats with osteoarthritis, including cats with evidence of concurrent CKD.

How much Robenacoxib can you give a cat?

Veterinarians generally prescribe robenacoxib to cats in a dosage of one 6 mg tablet administered once a day. They may prescribe two tablets to cats weighing over 13.3 pounds instead of just one.

What is the half life of Robenacoxib in dogs?

Robenacoxib has a short half-life in both dogs and cats, but tissue concentrations persist for much longer, which may explain the efficacy with once-daily dosing despite a short half-life. The half-life is 0.6-1.1 hours in dogs and 1.49, 1.87, 0.84, and 0.78 hours in cats (depending on the study).

How does Robenacoxib work for cats with arthritis?

The medication comes in tablet form and works by helping to combat the COX-2 enzyme that often causes pain in cats. The FDA has approved the drug for cats, and it requires a veterinarian’s prescription to purchase. You can easily order robenacoxib for your cat online from Chewy’s pharmacy with your vet’s prescription.

What is Robenacoxib for dogs used for?

Robenacoxib. Robenacoxib is approved for only dogs or both dogs and cats depending on the country. Indications in the dog are for treatment of pain and inflammation associated with orthopedic or soft-tissue surgery as well as the treatment of pain and inflammation associated with chronic OA (depending on the country).

Is Robenacoxib an NSAID?

Robenacoxib is an NSAID. Like other drugs in this class, robenacoxib has analgesic and anti-inflammatory effects by inhibiting the synthesis of prostaglandins. The enzyme inhibited by NSAID is the cyclooxygenase (COX) enzyme.

How do I give my Dog Robenacoxib?

How do I give my pet robenacoxib? Robenacoxib is available both as an injection and oral tablets. The injection is administered by your veterinarian at the hospital, and the tablets are given at home by mouth, with or without food. The tablets should be given whole and are not designed to be broken.

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Can a vet prescribe Robenacoxib in the US?

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. ONSIOR (robenacoxib) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) of the coxib class.

How to treat osteoarthritis in cats?

A multimodal approach is recommended to treat OA in cats. The basis of this approach is to use a combination of therapies that improve comfort and quality of life. It is important to note that all treatment decisions are made based on individual patients and in discussion with the pet owner and surgeon. Weight management.

What kind of pain medication can I give my Cat for OA?

Research regarding safety and dosing of these medications for OA in cats is ongoing. Adjunctive drug therapy Medications such as gabapentin, amantadine, and tramadol are being increasingly investigated for use in treating chronic pain in cats.

How many onsior (Robenacoxib) tablets should I take?

Dosage and Administration: Body weight 6 mg ONSIOR (robenacoxib) Tablet 5.5 to 13.2 lbs (2.5 to 6 kg) 1 whole tablet once daily 13.3 to 26.4 lbs (6.1 to 12 kg) 2 whole tablets once daily

What is the molecular weight of Robenacoxib?

Tablets are round, beige to brown in color, not scored, flavored and contain 6 mg robenacoxib. The molecular weight of robenacoxib is 327.28. The empirical formula is C16-H13-F4-NO2. Robenacoxib is [5-Ethyl-2- (2,3,5,6-tetrafluoro-phenylamino)-phenyl]-acetic acid.

How long can you give a cat Robenacoxib?

Length of approved treatment times in the cat varies from 3 to 11 days. Robenacoxib was shown to have a very good safety profile with daily administration in studies of 28 and 42 days in healthy young cats (5 to 8.5 months of age).

Is Robenacoxib safe for beagles?

Previous studies have demonstrated an excellent safety profile for robenacoxib when administered orally to healthy young beagle dogs at daily doses of up to 40 mg/kg for 1 month and up to 10 mg/kg for 6 months [ 8 ].

Are there any side effects of onsior for cats?

The concern with the new drug, Onsior®, is that similar problems might accompany its usage as well. So, while many veterinarians are cautiously optimistic about having a new option to relieve pain in cats, they are also somewhat fearful of the potential side effects of the medication.

How long can you give a dog Robenacoxib?

Unlike the other NSAIDs listed in the above table, ONSIOR (robenacoxib) is not approved for long-term use in dogs with osteoarthritis. It should only be used for a maximum of 3 days to control pain and inflammation after soft tissue surgery.

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What is Robenacoxib for cats and dogs?

Robenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs. with evidence-based and structured datasets.

How does Robenacoxib interact with nebivolol?

Robenacoxib may decrease the antihypertensive activities of Nebivolol. Robenacoxib may decrease the excretion rate of Nedaplatin which could result in a higher serum level. Robenacoxib may decrease the excretion rate of Nedocromil which could result in a higher serum level.

Is Robenacoxib used before or after surgery?

This drug is often used before and after surgical procedures because robenacoxib targets inflamed tissues. How do I give my pet robenacoxib? Robenacoxib is available both as an injection and oral tablets.

How much Robenacoxib can a dog take for arthritis?

Robenacoxib is used for the control of pain and inflammation associated with osteoarthritis, orthopedic and soft-tissue surgery in dogs (approved in EU), and for musculoskeletal disorders and soft-tissue surgeries in cats (approved in the US and EU). Dosage is 2 mg/kg, PO, initially and then 1–2 mg/kg per day thereafter (for up to 6 days in cats).

Is Robenacoxib annotated?

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon. Robenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs.

How much acetaminophen can I give my Dog for pain?

You can give your dog: 10 mg per kg of weight, by mouth, twice a day, with or after food. For example, most acetaminophen comes in 500 mg tablets, so a 30 kg Labrador could take three-fifths of a tablet twice a day, with food. The side effects are similar to aspirin.

How much Robenacoxib is safe for dogs?

Robenacoxib was well tolerated at doses from 2 to 10 mg/kg/day and this 6-month study supports the safe use of Onsior™ (robenacoxib) tablets in dogs for the intended dosing regimen. The non-steroidal anti-inflammatory (NSAID) drug robenacoxib has been developed for veterinary use in cats and dogs [ 1, 2 ].