What is a zebra danio lifespan?

Is the zebra danio a genetically modified fish?

In recent years the Zebra Danio has been genetically modified by introducing jellyfish genes, amongst others, to exhibit a glowing red colour. If you see these fish for sale we recommend you find out about the ethical concerns of such fish before you decide to purchase or avoid these fish.

Is zebrafish a suitable model organism for drug discovery and development?

The zebrafish and zebrafish larva is a suitable model organism for drug discovery and development.

Are zebra danios genetically modified animals?

However, zebra danios have been used to make genetically modified variants with types that express green, red and yellow fluorescent glo commercially available. That said, in this zebra danio guide, we are going to discuss everything you need to know including types, life, feeding, breeding, how to care for and so much more.

Can zebrafish be used as a model organism for drug discovery?

In this Review, we discuss recent advances in disease modelling using the zebrafish that have highlighted the potential of this model organism for discovering drugs and exploring drug mechanisms in vivo, as well as its utility as a whole-animal model for preclinical drug repurposing and personalized medicine.

What is the classification of a zebrafish?

The zebrafish is a derived member of the genus Danio, of the family Cyprinidae. It has a sister-group relationship with Danio aesculapii. Zebrafish are also closely related to the genus Devario, as demonstrated by a phylogenetic tree of close species.

Is zebrafish a marvel of high-throughput biology for 21st century toxicology?

“Zebrafish: A marvel of high-throughput biology for 21 st century toxicology”. Current Environmental Health Reports. 1 (4): 341–352. doi: 10.1007/s40572-014-0029-5. PMC 4321749. PMID 25678986.

Can zebrafish be used as a model organism for studying chemical toxicity?

^ Hill AJ, Teraoka H, Heideman W, Peterson RE (July 2005). “Zebrafish as a model vertebrate for investigating chemical toxicity”. Toxicological Sciences. 86 (1): 6–19. doi: 10.1093/toxsci/kfi110.

What can we learn from drug screens in zebrafish?

Drug screens in zebrafish can be used to identify novel classes of compounds with biological effects, or to repurpose existing drugs for novel uses; an example of the latter would be a screen which found that a commonly used statin ( rosuvastatin) can suppress the growth of prostate cancer.

Is the zebrafish a useful vertebrate animal for biomedical research and Drug Discovery?

Conclusion In summary, the zebrafish is a very useful vertebrate animal model in biomedical research and drug discovery.

What can zebrafish embryos tell us about drug development?

Zebrafish embryos absorb small molecules at physiological drug concentrations. Zebrafish can be screened for altered cell or tissue development marked by fluorescent reporters, or by other phenotypic assays.

What are the advantages of zebrafish as a model system?

The advantages of zebrafish as a model system can be applied to model human disease and drug treatments in the embryonic and adult stages. Hundreds of transparent zebrafish embryos are fertilized ex vivo and are easily accessible for gene editing, transgenics and small-molecule screening.

Can zebrafish be used as a model for human epilepsy?

Approximately 85% of known human single-gene epilepsy mutations have homologues in zebrafish, providing a framework for modelling additional rare genetic forms of epilepsy in zebrafish for drug screens.

How long ago was the zebrafish model?

“A model 450 million years in the making: zebrafish and vertebrate immunity”. Disease Models & Mechanisms. 5 (1): 38–47. doi: 10.1242/dmm.007138. PMC 3255542.

How is the zebrafish system used in drug discovery?

The uses of the zebrafish system span the length of the drug discovery pipeline from discovery-stage high-content, high-throughput screening through to preclinical models for therapy 175.

What can zebrafish teach us about cancer research?

Zebrafish are vertebrates and therefore have similar tissues and developmental biology to humans, and zebrafish models have been generated for a wide array of cancers 8, liver disease 9, blood disorders 10, heart disease 11 and behavioural disorders 12, 13, among others.

Can zebrafish be used as a model animal for genetic studies?

Introduction For use in genetic studies as an animal model, zebrafish was initially introduced by Streisinger and colleagues1in the early 1980s. Large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis was conducted in combination with extensive phenotypic screening2,3.

What is zebrafish?

This tiny fish is a v ersatile m odel organism f or many fields early de velopmen t. 1. Introduction in rece nt times. Zebrafish is a tropical fre shwat er fish, inhabitant of rive rs ( Ganges

What is the scientific name of zebrafish?

The zebrafish is known for its unique regenerative abilities and rapid embryonic development. The scientific name of zebrafish is Danio rerio and it belongs to the minnow family, Cyprinidae. The fish got its common name from the presence of five uniform and pigmented horizontal stripes on the side of its body, that resemble the stripes of a zebra.

Why are juvenile and adult zebrafish not used in clinical studies?

Apparently the main reason few studies have utilized juvenile and adult zebrafish is because the overarching value of zebrafish lies in its genetics and developmental biology. Several studies have exposed embryos to graded concentrations of a chemical and assessed endpoints of toxicity as juveniles.

Can zebrafish be used as a model of lipid metabolism?

Recently, zebrafish (Danio rerio), a small tropical freshwater fish which has been widely used as a vertebrate model to study embryogenesis, has gained popularity as a valuable model to study lipid metabolism and associated disorders.8,9,10,11,12,13

Can zebrafish contribute to the drug discovery and development pipeline?

The exciting and diverse range of zebrafish small-molecule screens and disease models has already firmly established zebrafish in the drug discovery and development pipeline and positions zebrafish to generate even more significant contributions to future therapeutics. 1. Howe, K. et al.

What are whole animal zebrafish screening assays?

Whole-animal zebrafish screening assays enable deep phenotyping of drug activity on organs and tissues at single-cell resolution. A wide range of screens have used assays that capture the dynamics of developmental biology, cell proliferation, cancer, infection and immunity, behaviour and toxicity, among others 17 (Fig. 2 ).

What can we learn from zebrafish drug screening?

Screening in zebrafish can also discover drugs that modulate the cell niche, rather than the target cell-type directly. This type of drug target would not be detected in cell-based and biochemical screens, which focus on a specific cell-type or protein target.

Is the zebrafish a marvel of high-throughput biology?

“Zebrafish: A marvel of high-throughput biology for 21 st century toxicology”. Current Environmental Health Reports. 1 (4): 341–352. doi: 10.1007/s40572-014-0029-5. PMC 4321749. PMID 25678986. ^ Dubińska-Magiera M, Daczewska M, Lewicka A, Migocka-Patrzałek M, Niedbalska-Tarnowska J, Jagla K (November 2016).