Is medaka a killifish?

How often do killifish lay eggs?

In the case of medaka and turquoise killifish, the number of eggs per oviposition seems smaller than that of zebrafish, but they lay eggs every day if the condition of the adult fish and aquarium is ideal. Medaka and turquoise killifish can show sexual maturation in approximately 2–3 months and 1 month, respectively.

What is the developmental process in zebrafish and medaka?

In zebrafish and medaka, the developmental process can be observed outside the body of the parent fish, and the embryos and larvae are transparent, making it easy to observe the developmental process and internal structure.

How long does it take for killifish to mate?

Medaka and turquoise killifish can show sexual maturation in approximately 2–3 months and 1 month, respectively. Compared to mice, the cost of subsequent management can also be greatly reduced.

Is the turquoise killifish the new model animal for age-related neurological diseases?

The turquoise killifish has emerged as a new and unique model animal, especially for ageing research due to its unique life cycle, and this fish also seems to be useful for age-related neurological diseases.

What can we learn from Medaka and zebrafish?

The pair of matching mutants in Medaka and zebrafish provides a good example of divergence of developmental modules: rx3 function is required in both Medaka and zebrafish for the development of the evaginated optic vesicle.

Do zebrafish and medaka regulate cardiac injury differently?

Enrichment analyses based on this dataset revealed important biological processes and signaling pathways differentially regulated between zebrafish and medaka following cardiac injury.

Is the transcriptome of medaka phylogenetically closely related to other species?

), direct comparison of the transcriptome of species that are phylogenetically closely related has not been reported. Medaka share characteristics with species that can regenerate their hearts, including low-metabolic state, poikilothermia, hypoxia, an immature CM structure, and an immature immune system, yet are incapable of heart regeneration (

What is the development of the turquoise killifish?

The turquoise killifish has a natural developmental adaptation, embryonic diapause, which makes it amenable to storing transgenic lines, without the need to maintain live breeders at all times. Killifish embryos can be kept in a dormant state for 3–6 months.

What can killifish be used for in environmental testing?

Of note, killifish has recently also been used for ecotoxicological testing regarding for example the effects of cadmium and copper [71], [72].

Is the turquoise killifish a good model for studying vertebrate aging?

The turquoise killifish (Nothobranchius furzeri) has recently been brought to the attention of the scientific community as a promising, new animal model system for studying the biology of vertebrate aging.

Is N furzeri an appropriate model for drug testing?

In this regard, the question arises whether N. furzeri might be an appropriate model for drug testing. The drug resveratrol, which has been shown to retard aging in a number of aging models like yeast, worm and fly, has indeed been shown to prolong life span and delay the onset of aging markers in N. furzeri [50].

Are zebrafish useful as animal models for human diseases?

In recent years, zebrafish, and to a lesser extent medaka, have become widely used small animal models for human diseases. These organisms have convincingly demonstrated the usefulness of fish for improving our understanding of the molecular and cellular mechanisms leading to pathological conditions …

Is the response to cryoinjury in medaka globally comparable to zebrafish?

). The gene expression changes after cryoinjury were temporally similar between zebrafish and medaka in component 2, yet less dynamic in medaka ( ). This finding may imply that the response to cryoinjury in medaka, although muted, is globally comparable to that in zebrafish.

Are turquoise killifish and Brandt’s bat receptors interrelated?

We mapped residues from the short-lived turquoise killifish, long-lived Brandt’s bat, and humans onto the well-studied IGF1 receptor (Figure 4D) and LMNA (Figure 4E). Many of the residues under positive selection in the turquoise killifish and the Brandt’s bat are in proximity on the IGF1 receptor sequence, but differ (Figure 4D).

Can African turquoise killifish teach us about longevity?

The African turquoise killifish provides a unique system to test the evolution and genetics of longevity ( Cellerino et al., 2015 ). This fish species comprises distinct populations that populate ephemeral ponds in arid regions of Zimbabwe and Mozambique ( Figures 1 A and 1B ).

What does the color of a killifish’s genetic variants mean?

For the turquoise killifish, color represents the strength of functional impact. We next mapped the variants under positive selection on the protein structures or domains of several aging-related proteins, highlighting variants with predicted functional effects (Tables S4E–G).

What can zebrafish teach us about learning and memory development?

Non-mammalian vertebrates such as zebrafish provide the opportunity to directly observe neurodevelopmental processes and determine the impact of developmental permutations on learning and memory. Zebrafish are particularly valuable because of the availability of morpholino techniques to transiently suppress specific parts of genomic expression.

What is the difference between zebrafish and medaka?

Concerning the immune response, zebrafish showed a stronger activation of genes involved in the complement system, macrophages, B cells, T cells, and phagocytosis, while medaka showed a stronger activation of genes related to neutrophil and monocyte chemotaxis ( ).

How was zebrafish and medaka husbandry performed?

All zebrafish and medaka husbandry was performed under standard conditions, and all animal experiments were done in accordance with institutional (MPG) and national ethical and animal welfare guidelines approved by the ethics committee for animal experiments at the Regierungspräsidium Darmstadt, Germany (permit numbers B2-1023 and B2-1111).

What is the zebrafish model of metabolic disease?

Zebrafish an animal models for metabolic research A high-calorie diet, a sedentary lifestyle, and a family history of metabolic disorders increase the prevalence of risk factors such as low HDL levels, high triglyceride levels, high blood glucose, high blood pressure, and abdominal obesity48.

Do Medaka share the same ability to regenerate the heart as zebrafish?

Zebrafish display a distinct ability to regenerate their heart following injury. However, this ability is not shared by another teleost, the medaka. In order to identify cellular and molecular bases for this difference, we performed comparative transcriptomic analyses following cardiac cryoinjury.