Are Golden zebra loaches aggressive?

Why does my Zebra loaches have white spots?

Zebra loaches are somewhat more susceptible to disease due to their minimal scales and sensitive head areas. Some experience with similar fish is ideal as they are sensitive to medications used to treat common tank diseases. Ich – this disease presents as white spots and is caused by a parasite.

Do zebrafish get sick from stress?

Stressed fish are more likely to get sick, after all, since stress depresses their immune system. Zebrafish are also highly susceptible to a chronic bacterial infection called Mycobacteriosis, which is especially common in laboratory colonies:

Is the zebrafish a good model of stress?

The zebrafish (Danio rerio) is emerging as a promising model organism for experimental studies of stress and anxiety. Here we further validate zebrafish models of stress by analyzing how environmental and pharmacological manipulations affect their behavioral and physiological phenotypes.

Are there viral diseases in zebrafish?

At present, there are no known viral diseases of zebrafish colonies. However, as has been the case with other relatively new forms of fish culture, as fish health researchers thoroughly investigate outbreaks and incorporate tissue culture in their examinations, it is very likely that “new” viral diseases will be recognized in zebrafish.

What causes anxiety in zebrafish?

These fish are also highly sensitive to various environmental challenges, including novelty stress, exposure to predators, alarm pheromone, anxiogenic drugs, and drug withdrawal. In addition, varying levels of baseline anxiety can be observed in different strains of zebrafish.

Do adenylate cyclase inhibitors cause anxiety in zebrafish?

PDE inhibitors or activators of adenylate cyclase cause behaviors consistent with anxiety in larvae and adult zebrafish. Small-molecule screening identifies MEK inhibitors as potent suppressors of cAMP anxiety behaviors in both larvae and adult zebrafish, while causing no anxiolytic behavioral effects on their own.

How does acute stress affect the performance of zebrafish in cognitive tests?

Gaikwad S, Stewart A, et al. Acute stress disrupts performance of zebrafish in the cued and spatial memory tests: the utility of fish models to study stress-memory interplay. Behav Processes. 2011;87(2):224–30. [PubMed] [Google Scholar]

Can zebrafish be used as an animal model of anxiety?

Zebrafish (Danio rerio) are rapidly emerging as a useful animal model in neurobehavioral research. Mounting evidence shows the suitability of zebrafish to model various aspects of anxiety-related states.

How are zebrafish similar to humans?

1. Genetic similarity to humans Zebrafish are vertebrates and therefore share a high degree of sequence and functional homology with mammals, including humans. Due to the conservation of cell biological and developmental processes across all vertebrates, studies in fish can give great insight into human disease processes.

What are the advantages of using zebrafish to model human diseases?

Zebrafish have several advantages compared to other vertebrate models used in modeling human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, and other biomedical research applications.

Are there any studies on T-all in zebrafish?

There have been many studies done in zebrafish since the first model of Myc-induced T-ALL [42]. A Cre-lox regulated conditional model of zebrafish T-ALL was developed because the original rag2-mMycexpressing zebrafish developed severe disease phenotypes and typically died around three months of age [66].

Are zebrafish the new model species for stress research?

Zebrafish (Danio rerio) are rapidly emerging as a promising new model species in stress research, characterized by complex behaviors in all major neurobehavioral domains and high genetic and physiological similarity with humans.

How does acute stress affect the performance of zebrafish in memory tests?

Gaikwad S, et al. Acute stress disrupts performance of zebrafish in the cued and spatial memory tests: the utility of fish models to study stress-memory interplay. Behavioural processes. 2011;87:224–230.

How do zebrafish respond to stress?

Similar to humans, stress responses in zebrafish are mediated by cortisol activated by the cascade of hypothalamo-putuitary hormones and acting via glucocorticoid receptors12, 13, 15, 147. For example, zebrafish cortisol responses strongly parallel behavioral indices of stress, and may be modulated genetically and pharmacologically12, 13, 42, 121.

What are the different forms of stress in zebrafish?

Figure 7: A summary of different forms of stress used in zebrafish neurobehavioral research. Fear – more anxious zebrafish strains (genetic differences). apparatus. The longer latency indicates top. Shorter average entry duration higher stressed fish. phenotypes. Zebrafish are generally quite

What is the neuroendocrine response of a zebrafish?

Zebrafish neuroendocrine responses are robust, and correlate strongly with behavioral endpoints. These fish are also highly sensitive to various environmental challenges, including novelty stress, exposure to predators, alarm pheromone, anxiogenic drugs, and drug withdrawal.

Can behavioral assays characterize anxiety-related behavioral phenotypes in zebrafish?

Several behavioral assays are currently used for high-throughput neurophenotyping and screening of genetic mutations and psychotropic drugs in zebrafish (Danio rerio). In this protocol, we describe a battery of two assays to characterize anxiety-related behavioral and endocrine phenotypes in adult z …

Is the zebrafish a vertebrate?

Early Development in Fish In recent years, the teleost fish Danio rerio,known as the zebrafish, has become a favorite organism of those who wish to study vertebrate development.

Why study the brain of a zebrafish?

Zebrafish are useful for studying the functional role of novel genes in neuronal development through directed expression studies of the zebrafish nervous system (Fig. ​(Fig.1b1b)28. In addition, recently, tissue-clearing technology has allowed visualization of neural networks in the whole brain of adult zebrafish (Fig. ​(Fig.1c).1c).

How many cells are born in a zebrafish brain?

Around 6000 cells are born within every 30 min period in the adult zebrafish brain, representing ≈ 0.06% of the estimated 107 cells of the zebrafish brain [31]. This widespread neurogenic activity has made the zebrafish an attractive model for the study of adult neurogenesis.

What can zebrafish tell us about ovarian development?

Zebrafish has emerged as an excellent model system to study the control of ovarian development. Dozens of genes related to ovarian development have been knocked out in zebrafish in recent years. Much new information and perspectives on the molecular mechanism of ovarian development have been obtained from these mutant zebrafish.

How is the brain of a zebrafish different from a mammal?

Although zebrafish are different to mammals in organization structure of the central nervous system, several cerebral nuclei in the zebrafish brain including the basal ganglia, striatum, hippocampus and amygdala have high homogeneity to mammals (Randlett et al., 2015).

Why study Parkinson’s disease in zebrafish?

Zebrafish have been utilized to investigate both neurotoxic and genetic effects in PD for more than 20 years and show great value in screening potential therapeutic drugs. Neurotoxic Zebrafish Models of Parkinson’s Disease Neurotoxins induce rapid loss of nigrostriatal dopaminergic neurons in animal models.

What are the advantages of using zebrafish for drug discovery?

Zebrafish have a number of advantages and provide an important foundation for the determination of NDD pathogenesis and drug discovery. In vitrochemical screening provides much higher throughput than in vivo, while in vivomodels can simulate complex systems in the human body such as the BBB.